HPLC Assay with Ultraviolet Detection for Therapeutic Drug Monitoring of Sirolimus
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منابع مشابه
HPLC assay with ultraviolet detection for therapeutic drug monitoring of sirolimus.
clinical practice. Clin Chem Lab Med 1998;36:163–8. 7. Weinstein RS, Jilka RL, Parfitt AM, Manolagas SC. Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. J Clin Invest 1998;102:274–82. 8. Dempster DW. Bone histomorphometry in glucocorticoid-induced osteoporosis. J Bone Miner Res 1989;4:137–41. 9. Saag KG, Emkey R, Schnitzer TJ, Brown ...
متن کاملValidation of an assay for routine monitoring of sirolimus using HPLC with mass spectrometric detection.
mus Using HPLC with Mass Spectrometric Detection, David W. Holt, Terry Lee, Kirsty Jones, and Atholl Johnston ( St. George’s Hospital Medical School, London SW17 0RE, United Kingdom; 2 St. Bartholomew’s & The Royal London School of Medicine & Dentistry, London EC1M 6BQ, United Kingdom; * address correspondence to this author at: Analytical Unit, St. George’s Hospital Medical School, London SW17...
متن کاملTherapeutic Drug Monitoring of Sirolimus,Correlation With Laboratory Parameters In Transplant Patients
Sirolimus is a potent immunosuppressive agent administered as prophylactic agent to prevent rejection after organ transplantation. Sirolimus must be used within a narrow therapeutic window. Due to inter- and intra-variability, sirolimus blood concentrations may be affected, therefore, there is no possibility of predicting the sirolimus blood concentrations based on the dose patients received. T...
متن کاملRoutine clinical monitoring of sirolimus (rapamycin) whole-blood concentrations by HPLC with ultraviolet detection.
During phase I/II clinical trials of sirolimus (rapamycin; SRL), therapeutic drug monitoring was performed with a multistep liquid-liquid extraction of 1-mL aliquots of whole blood followed by reversed-phase HPLC with ultraviolet detection. Blood was sampled according to a standardized protocol and clinical status. SRL concentrations were interpolated from calibration curves with a linear range...
متن کاملtherapeutic drug monitoring of sirolimus,correlation with laboratory parameters in transplant patients
sirolimus is a potent immunosuppressive agent administered as prophylactic agent to prevent rejection after organ transplantation. sirolimus must be used within a narrow therapeutic window. due to inter- and intra-variability, sirolimus blood concentrations may be affected, therefore, there is no possibility of predicting the sirolimus blood concentrations based on the dose patients received. t...
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ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 2001
ISSN: 0009-9147,1530-8561
DOI: 10.1093/clinchem/47.7.1316